LYCOCARD will investigate the role of lycopene in reducing the risk of cardiovascular diseases, adopting a “total food chain” approach by addressing each link in a “farm to fork” approach for future projects to increase the understanding of diet and health. Specifically, LYCOCARD will clarify the following points: Effects of technological processing on lycopene, interactions between different food ingredients, molecular aspects of absorption and metabolism of lycopene, biological effects of lycopene isomers and lycopene metabolites. This information will lead to improved nutritional guidelines and healthy new foods based on tomatoes and other dietary sources containing lycopene. These novel dietary guidelines will help consumers to select specific diets which protect them against disease risk. LYCOCARD will therefore improve the health of European consumers and reduce the costs of health systems, while also significantly advancing the state of the art. In addition, the position of the European food industry will be strengthened by increasing the demand for health-related tomato products and other newly developed healthful foods.